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CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis), CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system. In this video, I discuss what we know about CBD’s mechanism of action and its potential in treating various conditions like epilepsy and anxiety.
TRANSCRIPT:
CBD is one of a class of compounds known as cannabinoids, which are found in the cannabis plant. Unlike THC (the main psychoactive component of cannabis) CBD is not thought to have intoxicating effects. It is, however, believed to interact with the nervous system, which may enable it to modulate the effects of thc as well as have actions of its own.
CBD is chemically similar to THC, but it does not have the same mechanism of action, and some evidence suggests it may even interfere with some of the actions of THC. One way it may do this is by binding to receptors that THC binds to known as CB1 receptors, but instead of activating them, causing a change in the receptor that reduces THC’s ability to interact with it. This type of effect is known as negative allosteric modulation, and it may enable CBD to mitigate some of the adverse effects of THC, like anxiety. Other research, however, suggests CBD can enhance certain effects of THC, and CBD is also thought to act at a number of other targets besides the CB1 receptor. For example, CBD is believed to activate serotonin receptors and may increase levels of a natural cannabinoid called anandamide by blocking anandamide reuptake and inhibiting the enzymatic breakdown of anandamide. Overall, although a number of targets for CBD have been identified, its mechanism of action is still poorly understood.
CBD is generally well-tolerated, but some have raised concerns about the need for more research before we can be confident about its safety in all populations. CBD, however, is not thought to have potential for abuse, and some believe it does have potential for treating a number of conditions, like anxiety, insomnia, and pain. But most of these claims don’t yet have strong evidence to support them, and more research is needed, although CBD has been found to be a viable treatment for at least some types of epilepsy.
REFERENCES:
Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015;172(20):4790-4805. doi:10.1111/bph.13250
McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol. 2015;172(3):737-753. doi:10.1111/bph.12944
Pisanti S, Malfitano AM, Ciaglia E, et al. Cannabidiol: State of the art and new challenges for therapeutic applications. Pharmacol Ther. 2017;175:133-150. doi:10.1016/j.pharmthera.2017.02.041
World Health Organization (WHO). Cannabidiol (CBD): Pre-Review Report. November 2017. Accessed June 28, 2020. https://www.who.int/medicines/access/controlled-substances/5.2_CBD.pdf
Special thanks to Srikar Gade for help with fact-checking this video.
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CBD Oil for Cavalier King Charles Spaniels – How Cannabis Hemp Tincture Can Help
Cavalier King Charles Spaniels is one of the various breeds of companion dogs. They have a normal lifespan of 9 years to 14 years. Cavalier King Charles Spaniels can be said to have everything a person would want from his dog. They usually have a quiet temperament and are rather loving and affectionate. These spaniels simply want to have some cuddle time with their owners and play as long as possible.
Health Conditions That Normally Effect Cavalier King Charles Spaniels
Although healthy breeds, Cavalier King Charles Spaniels do show signs of having some specific health problems. These include patellar luxation or dislocation of the kneecap while playing or exercising, hip dysplasia or a situation wherein the femur bone isn’t able to fit properly in the pelvis, cataracts or eye problem that is normally hereditary, and PSOM or Primary Secretory Otitis Media or better known as “glue ear” in which a thick layer of mucus forms inside the ear.
How Can CBD Oil Help Cavalier King Charles Spaniels?
As discussed above, Cavalier King Charles Spaniels are extremely cuddly and loving. It will naturally break your heart to find your spaniel suffering from any of the above mentioned health problems. Vets are there to help with a variety of suitable medications. However, there is no guarantee that these medications will not come with side effects. The best solution is CBD oil.
There have been numerous tests and studies on CBD and it has been determined that it contain pain relieving and anti-inflammatory properties. This will help your spaniel get immense relief from physical aches and get back to its normal playful self. Problems such as hip dysplasia that causes great pain, can easily be calmed with the help of CBD oil. This substance from the cannabis plant also has anti-anxiety properties that help your dog remain calm even if left alone.
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In this video, I will show you the complete grow cycle of my Whitw Widow CBD autoflower from Dutch passion seed company. I have grown this strain before in my micro grow PC box setup and now I am using the CNNBS G Kit from CNNBS and G Tools. I Use a Mars Hydro LED system that works great in this grow room.
In this video, I will also tell you about the future of my YouTube channel and how I will continue and which grow setup i will use. I will show you a complete photo lapse like always and i will give you an explanation how i grow the CBD auto flower plants from seed to harvest. Get ready to see some nice frosty (CBD) buds 🙂
In this video you will also see the grow stage of my Royal Cheese autoflower plant from Royal Queen Seeds. I will show you how i apply Low Stress Training (LST) and how i grow a big plant in a small space. Of course a PC micro setup is a lot more challenging and you will see more of that in the upcoming videos.
IM happy to be back and to bring you this new Weed VLOG i hope you enjoy it because it was a joy making it for you! Thank you so much for the support these last 3 years. I will continue to make micro grow videos in the cool setups that i have shown before. With your support, we can make this into something big. Much love.
Whitw Widow CBD from Dutch Passion Seed company
CBD Auto White Widow uses the original Dutch Passion Auto White Widow crossed with CBD Sweet and Sour Widow by The CBD Crew to create a 1:1 THC:CBD variety. CBD and THC levels can both exceed 9% or 10% in good growing conditions, this is the strongest 1:1 auto we have yet seen.
CBD Auto White Widow may be useful for medical growers looking for the CBD-rich variety which is easy to grow and delivers stronger than average medical effects. Its easy to grow under 20 hours of daily light, and can be harvested around 9-10 weeks after germination with yields that are above average. Powerful medical relief.
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Is he being too cautious, or is this a disaster waiting to happen? Let’s dive into this high-stakes Reddit story about legality, relationships, and where to draw the line.
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Is your cat ruining your sleep? We’ve all been there, trying to sleep when suddenly the cat is plowing through the house on some feline adventure. When your cat is rambunctious at night or pressing you for attention, it can be really difficult to get a good night’s sleep.
Cats are naturally more active at night in the wild, but for your indoor kitty, they can adjust to your schedule and sleep more during the day. If your cat’s late-night shenanigans keep you from sleeping, there are ways to retrain your cat and modify your own behavior so you can get more sleep at night. CBD oil products for cats can help too! We’ll cover what you can do differently and how to use CBD oil for cats to restore the peace in your home at night.
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From eye cream to undergarments, CBD is popping up everywhere these days. But for something so widely available, it can be challenging to figure out how and why to best use CBD. To help, here are some of the first steps to take when choosing a CBD product.
Understand what CBD can (and can’t) do
It may seem like CBD is being touted as a cure-all and maybe it is. Until Federal regulations evolve and allow for objective cannabis research, we will not know the full range of cannabis’ benefits. Still, the experts have some advice, and researching your condition to find the recommended formulation of cannabinoids and terpenes beforehand can help set expectations and point you in the right direction as you start your search.
How do you want to take CBD?
The way you consume CBD will help determine how it makes you feel. For fast-acting relief, inhaling CBD or using a tincture may be most effective as the benefits can be felt throughout the body within minutes and last for 1-3 hours. On the other hand, digesting CBD edible gummies or soft gels take longer for the body to absorb into your system and will stay in your system longer. Edibles usually have an onset time of 1-2 hours and effects can last up to 8 hours. Topical applications like our pain cream are good for targeted relief, but studies show minimal benefit outside of the area it is applied so best for treatment surface-level conditions.
How much CBD should I take?
It’s a good thing that CBD is non-psychoactive because finding your dose can take time. Everyone’s body processes cannabis differently so finding what works best for your specific needs is important. Look for products that contain full-spectrum CBD and other minor cannabinoids. For Care By Design drops start with ½ – 1 ml and for soft gels start with 1 soft gel. Note how you feel after a few hours. It may be helpful to use a journal to record changes in mood, sleep, relief of symptoms, etc. Try the same or similar doses for several days, as CBD has a cumulative benefit, and studies show that CBD’s effects build with regular and prolonged use.
Not all CBD is created equal.
Full-spectrum CBD has shown to be most effective as it mimics the composition of the cannabis plant. This creates what is known as the entourage effect, the idea that the sum of cannabis’ compounds is greater than that of the individual parts. Care By Design uses full-spectrum oil and complimentary ingredients like MCT oil which aid the body’s absorption of cannabinoids as well as terpenes that create scientifically proven sensory effects. The alternative to full-spectrum oil is typically CBD isolates, synthetic terpenes, or over-processed oil with minimal cannabinoid and terpene content. Avoid products with synthetic flavorings and additives as these are often filler ingredients with no medicinal benefit.
Great CBD starts with great plants
Location, location, location. Where and how the plants are grown is key to efficacy. Imported CBD has little regulatory oversight or transparency into production conditions. Because regulations and standards vary by state and country, we only source sun-grown CBD sourced and manufactured in California because established markets have more stringent regulations and better infrastructure in place to assess product safety and quality.
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Care By Design™ products have not been evaluated by the Food and Drug Administration (FDA). This information is not intended to diagnose, treat or cure any disease. This information should not be interpreted as medical advice or treatment. You should consult your physician or other health care professional before starting any medication or supplements. Further, Care By Design™ does not manufacture, sell or distribute any products that are in violation of California State Law.
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Parkinson’s disease, also known as PD, is the second most common neurodegenerative disorder. The disease is characterized by a loss of dopamine-producing neurons in the substantia nigra, which is an area of the brain responsible for movement. Cannabis, specifically CBD, has shown promise in treating some of the symptoms of PD. In this video we will define Parkinson’s disease and cannabis, explain how cannabis can help with PD, and physician perspectives on prescribing cannabis.
This video was created by Demystifying Medicine students Simran Matharu, Mahek Minhas and Micaela McNulty in collaboration with the McMaster Demystifying Medicine Program
Copyright McMaster University 2021
For more information visit:
https://www150.statcan.gc.ca/n1/pub/82-003-x/2014011/article/14112-eng.htm
Time Stamps:
Introduction/What is Parkinson’s Disease? → 00:00 – 01:23
What is Cannabis? → 01:24 – 02:34
How Can Cannabis Help With Parkinson’s? → 02:35 – 05:09
Physician Perspectives → 05:10 – 07:19
Conclusion → 07:20 – 07:52
References:
Bega, D., Simuni, T., Okun, M. S., Chen, X., & Schmidt, P. (2016). Medicinal cannabis for Parkinson’s disease: Practices, beliefs, and attitudes among providers at national Parkinson Foundation centers of excellence. Movement Disorders Clinical Practice, 4(1), 90-95.
Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Pisarev, V. M., Tsiperson, V., Nemachek, C., Ciborowski, P., Przedborski, S., Mosley, R. L., & Gendelman, H. E. (2008). Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PloS one, 3(1), e1376.
Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology, 56, 235–243.
de Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525–535.
Edelstein, O. E., Wacht, O., Isralowitz, R., Reznik, A., & Bachner, Y. G. (2020). Beliefs and attitudes of graduate gerontology students about medical marijuana use for Alzheimer’s and Parkinson’s disease. Complementary Therapies in Medicine, 52, 102418.
Gardiner, K. M., Singleton, J. A., Sheridan, J., Kyle, G. J., & Nissen, L. M. (2019). Health professional beliefs, knowledge, and concerns surrounding medicinal cannabis – A systematic review. PLOS ONE, 14(5), e0216556.
Hauser, R. A., Rascol, O., Korczyn, A. D., Jon Stoessl, A., Watts, R. L., Poewe, W., De Deyn, P. P., & Lang, A. E. (2007). Ten-year follow-up of Parkinson’s disease patients randomized to initial therapy with ropinirole or levodopa. Movement disorders: official journal of the Movement Disorder Society, 22(16), 2409–2417.
Jankovic, J. (2008). Parkinson’s disease: Clinical features and diagnosis. Journal of Neurology, Neurosurgery & Psychiatry, 79(4), 368–376.
Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L. E., Huang, X.-F., Liu, K., Arnold, J. C., & McGregor, I. S. (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443–457.
Lang, A. E., & Lozano, A. M. (1998). Parkinson’s Disease. New England Journal of Medicine, 339(16), 1130–1143.
Laun, A. S., & Song, Z. H. (2017). GPR3 and GPR6, novel molecular targets for cannabidiol. Biochemical and biophysical research communications, 490(1), 17–21.
Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B., Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., & Tanner, C. (2018). Prevalence of Parkinson’s disease across North America. Npj Parkinson’s Disease, 4(1), 21.
Nutt J. G. (2000). Response to L-dopa in PD: the long and the short of it. Neurology, 54(10), 1884–1885. https://doi.org/10.1212/wnl.54.10.1884
Oeckl, P., Hengerer, B., & Ferger, B. (2014). G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson’s disease. Experimental neurology, 257, 1–9. https://doi.org/10.1016/j.expneurol.2014.04.010
Severe Spasticity. (2020). https://lioresal.com/severe-spasticity/.
Venderová, K., Růzicka, E., Vorísek, V., & Visnovský, P. (2004). Survey on cannabis use in Parkinson’s disease: subjective improvement of motor symptoms. Movement disorders: official journal of the Movement Disorder Society, 19(9), 1102–1106. https://doi.org/10.1002/mds.20111
Wang, M., Wang, Y.-H., Avula, B., Radwan, M. M., Wanas, A. S., Mehmedic, Z., van Antwerp, J., ElSohly, M. A., & Khan, I. A. (2017). Quantitative Determination of Cannabinoids in Cannabis and Cannabis Products Using Ultra-High-Performance Supercritical Fluid Chromatography and Diode Array/Mass Spectrometric Detection. Journal of Forensic Sciences, 62(3), 602–611. https://doi.org/10.1111/1556-4029.13341
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How do you know how much THC and CBD is in your weed?
For many of you, your knowledge of cannabis may only extend to the fact that when smoked, it gets you high.
Some users will go as far as to say that some types of cannabis will get you more stoned than others, but that is a bit like saying that some beers get you pissed more quickly than others. It’s all about the strength.
However, with cannabis, that isn’t exactly true.
Some of you may well know that it is the THC, one of over 100 cannabinoids found in the cannabis plant, that is actually responsible for the ‘high’ associated with the drug.
There again, because CBD, another cannabinoid found in the cannabis plant, is responsible for the mellow side of things, then the high you get from cannabis is the result of the ‘balance’ created by the combined levels of THC and CBD.
So, in simple terms, the higher the levels of CDB and lower the levels of CBD, the more aggressive and high the actual high from smoking that cannabis will be.
But how do you know what these levels are. After all, unlike brewing beer, which involves exact measurements of time, ingredients and temperatures, growing cannabis produces different results under different conditions.
Pharmaceutical-grade CBD products have to accurately indicate the levels of that cannabinoid, which makes sense when, for many, it is taken for medicinal purposes.
So, let’s say you want to smoke some cannabis to help you with feelings of anxiety. Research shows that CBD is good for treating anxiety, yet THC most definitely isn’t good. Maybe now you will understand the importance of knowing how strong the levels of both those cannabinoids are in your cannabis.
Thanks to careful breeding and the creation of new strains of cannabis, it is now possible to buy cannabis where, while the levels aren’t totally accurate, you know if what you are going to be smoking is richer in THC or CBD.
Basically, it’s all in the name and the strain.
Sativa cannabis strains are more usually associated with the “head high”, while indicas are richer in CBD and more the stuff or body relaxation.
To give you some examples, if you are looking for cannabis that has a THC content in the region of 20% (that’s loads of THC!), then Kosher Kush, Ghost OG and Bruce Banner should be ‘high’ on your shopping list.
If you are more of a CBD fan, then Ringo’s gift is great with a 24:1 CBD to THC ratio, or ACDC which has a 20:1 CBD to THC ratio.
So, when you want to know how much CBD or THC is in your weed, the answer is usually in the name…
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Coca-Cola is allegedly ‘in talks’ with Canadian cannabis manufacturer, Aurora Cannabis, to consider a drink featuring cannabidiol, which comes from cannabis, as one of the major ingredients.
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You might be aware that CBD is a popular health product, but did you know that your pets can benefit from it, too?
Recent research shows that dogs, in particular, could benefit from CBD oil. Many veterinarians and animal lovers claim that CBD for pets can be used as an anti-inflammatory and to soothe anxiety, pain, and even skin conditions in dogs. Many people also use it as a preventative measure to enhance their dogs’ overall health and wellbeing.
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Updated meiosis video. Join the Amoeba Sisters as they explore the meiosis stages with vocabulary including chromosomes, centromeres, centrioles, spindle fibers, and crossing over. Expand details to see table of contents 👇 This video also compares meiosis with mitosis. This video has a handout here: http://www.amoebasisters.com/handouts.html
Major Points in Table of Contents:
Intro 00:00
Mitosis vs. Meiosis Comparison 0:17
Gametes and Chromosome Count Compared to Body Cells 0:46
Interphase 1:44
Meiosis I 3:36
Crossing Over (in Prophase I) 3:56
Meiosis II 5:25
End Result of Meiosis 6:17
The Amoeba Sisters videos demystify science with humor and relevance. The videos center on Pinky’s certification and experience in teaching biology at the high school level. For more information about The Amoeba Sisters, visit:
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⭐We have a menu of our resources that complement our videos! Visit https://docs.google.com/spreadsheets/d/1b3kmAzFEjWgoMKCrkeNCKFYunWk04IuLY93jI4OY0gY/edit?usp=sharing
We cover the basics in biology concepts at the secondary level. If you are looking to discover more about biology and go into depth beyond these basics, our recommended reference is the FREE, peer reviewed, open source OpenStax biology textbook: https://openstax.org/details/books/biology
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Our Resources:
Biology Playlist: https://www.youtube.com/playlist?list=PLwL0Myd7Dk1F0iQPGrjehze3eDpco1eVz
GIFs: https://www.amoebasisters.com/gifs.html
Handouts: https://www.amoebasisters.com/handouts.html
Comics: https://www.amoebasisters.com/parameciumparlorcomics
Unlectured Series: https://www.amoebasisters.com/unlectured
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TIPS FOR VIEWING EDU YOUTUBE VIDEOS:
Want to learn tips for viewing edu YouTube videos including changing the speed, language, viewing the transcript, etc? https://www.amoebasisters.com/pinkys-ed-tech-favorites/10-youtube-tips-from-an-edu-youtuber-duo
MUSIC:
Music in this video is listed free to use/no attribution required from the YouTube audio library https://www.youtube.com/audiolibrary/music?feature=blog
COMMUNITY:
We take pride in our AWESOME community, and we welcome feedback and discussion. However, please remember that this is an education channel. See YouTube’s community guidelines and how YouTube handles comments that are reported by the community. We also reserve the right to remove comments.
TRANSLATIONS:
While we don’t allow dubbing of our videos, we do gladly accept subtitle translations from our community. Some translated subtitles on our videos were translated by the community using YouTube’s community-contributed subtitle feature. After the feature was discontinued by YouTube, we have another option for submitting translated subtitles here: https://www.amoebasisters.com/pinkys-ed-tech-favorites/community-contributed-subtitles We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. If you have a concern about community contributed contributions, please contact us.
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This clip is a short excerpt from the documentary “Hemp – A journey”. In this film I am making a trip to find out more about hemp, its perception and what it is used for today.
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